SC 281 Ellenton to Barnwell 1924 Blue Book

SC 64 created from Ellenton to Ruffin 1926 Official

Adjustments: In 1928, SC 64 was extended east replacing SC 6 to US 17 (now US 17 ALT) Walterboro.
In 1929, SC 64 was extended east as new primary routing to Cottageville, then was shown as a projected highway east through Summerville to Moncks Corner.

SC 64 extended to Walterboro 1928 Standard Draft

SC 64 extended to Cottageville 1929 Official

In 1930, SC 64 was opened from Cottageville to US 78/SC 2 Summerville.
In 1932, SC 64 was removed from today's S-15-208 Dorsey Rd northwest of Walterboro.
In 1933, SC 64 was removed from S-6-69 River Rd/S-6-20 Patterson Mill Rd west of Barnwell.
In 1934 or 1935, SC 64 was opened from Summerville to US 52 Moncks Corner.

SC 64 extended to Summerville 1928 Standard Draft

SC 64 extended to Moncks Corner 1935 Official

By 1937, SC 64 was removed from S-8-61 Old Summerville Rd.
Between 1944-50, SC 64 was removed from Old Air Base Rd (now cutoff by the lumber yard) east of Walterboro.

SC 64 original east Walterboro route 1943 Colleton County

SC 64 straightened east Walterboro route 1950 Colleton County

In 1950, SC 64 was extended west with SC 28 to end at SC 781 (now US 278) Beech Island; SC 64 east was extended with US 52, then replaced SC 179 to Jamestown, north with SC 511 across the Santee River, then replaced SC 528 to end at US 521 near Sampit. SC 64 was 181 miles at this point.
In 1952, SC 64 east was truncated to Walterboro, with the old route to Sampit becoming US 17 ALT.

SC 179-528 Moncks Corner to Sampit 1949 Official

SC 64 extended to US 521 1950 Official

SC 64 replaced by US 17 ALT
1952 Official

SC 63 Walterboro to Jacksonboro 1951 Official

SC 64 Walterboro to Jacksonboro 1953 Official

Also in 1953, SC 64 west was truncated to the Savannah River Site boundary, leaving behind SRS Route B, SC 125 and S-2-5.

SC 64 extended west to Beech Island 1950 Official

SC 64 truncated to SRS boundary at Snelling 1953 Official

Between 1953-56, SC 64 was removed from S-6-1 Burr St/S-6-11 Main St and placed on Hagood Ave over to SC 28 (now US 278) Jackson St.

SC 64 through central Barnwell 1952 Barnwell County

SC 64 removed from central Barnwell 1956 Barnwell County

Between 1983-85, the Walterboro Bypass was built. It was first signed as P-1501, but sometime in the late 80s became SC 64 Bypass. County maps up through at least 1995 still showed it as P-1501.

P-1501 around Walterboro 1986 Colleton County

SC 64 around Walterboro 2005 Colleton County

Improvements: By 1932, SC 64 was paved from Earhardt to Walterboro.
In 1933, SC 64 was paved from Ellenton to Barnwell and from Summerville to US 78.
In 1934, SC 64 was paved most of the way from Barnwell to Olar.
In 1935, SC 64 was partially paved west of Moncks Corner.
In 1936, SC 64 was paved completely to Olar, and more of Berkeley County.
In 1937, SC 64 was paved from Walterboro to Moncks Corner.
In 1939, the last section of SC 64 to be paved was completed between Olar and Ehrhardt.
SC 64 was 4-laned from Barnwell west to the Savannah River Plant in 1953.
In 1973, SC 64 was 4-laned on its US 301 multiplex.
In 1976, SC 64 was 4-laned from I-95 to Walterboro.
When SC 64 was moved onto the Walterboro bypass, it was 4-laned.
Comment: SC 64 serves as a decent alternative from Charleston (via US 17) to the Augusta, GA area (via SC 641 and SC 125).