WV 29 from Wheeling to Pennsylvania 1922 Official

US 40 replaces WV 29 1928 Official

Adjustments: Sources are a bit confusing but it appears by 1935, US 40 was rerouted in Wheeling to use 10th St to Chapline to Stone Blvd north out of downtown. Originally US 40 had a one-way pair with Market and Main, with Pike St for US 40 WB and 10th St for EB. Intersetingly, WV 2 used 7th St as it does today.
In 1937 (WVDOH), US 40 was removed from Logan Rd east of Valley Grove.
In 1939 (WVDOH), US 40 was removed from Camino Rd at the Pennsylvania line and placed on its West Alexander PA bypass.
In 1955, US 40 was removed from the Wheeling Suspension Bridge, plus Zane St south of I-70 and routed onto the current I-70 bridge. With this reroute, it appears US 40 was given its current one-way splits in Wheeling with EB using Main St south to 10th east to Market northbound. Westbound US 40 uses 7th St to Main St south to I-70. The Wheeling Suspension Bridge was designated as US 40 ALT (now WV 251).

US 40 original Wheeling route 1927 Official

US 40 moved to Stone Blvd 1937 Ohio County

US 40 removed from Suspension Bridge US 40 removed from Stone Blvd 1964 Champion

Improvements: Fully paved upon inception
US 40's multilaning is all associated with I-70 or its one-way split in Wheeling.
Comment: US 40 is the National Highway and mostly runs on its original alignments.
US 40 is not particularly useful as a through route on its West Virginia segment.