Bristol: US 11 used State St east into central Bristol, then Front St north to Spencer St northeast to Mary St east to Goodson St north to Danville Ave east to Fairview St north to Massachussetts Av east to Texas Av north which becomes Old Abingdon Hwy. which runs back into US 11-19 near the I-81 interchange.
Adjustments:In 1929, US 11 along State St became US 11W. US 11's south end became Front St at State St.
In Feb 1930 (CTB), US 11 was rerouted to use Piedmont Ave north from State St to Euclid, then northeast out of town. Mary St/Goodson St/Danville Ave/Fairview St/Massachusetts Ave became part of an extended VA 109, but Texas Ave and Old Abingdon Hwy became SR 645 (now all within the City of Bristol and unnumbered now).
In Dec 1966 (CTB), US 11 was removed from Piedmont and kept on Euclid southwest to Commonwealth as it runs today. Some of Piedmont became VA 113.

US 11 original Bristol route 1929 Official

US 11 ends further west on State 1937 Official

Current US 11 in Bristol (labeled US 11-421) 1988 Official

Bristol through Wytheville: US 11 followed its modern routing approaching Abingdon, then used Colonial Ave and crossed the railroad to modern US 11 at roughly the Bytt St location. In eastern Washington County US 11 followed its modern route except for the SR 754 loop. US 11 used its current alignment to Chillhowie where it followed Main St (no longer connects back to Lee Hwy), except I-81 has broken up the actual US 11 alignment (for example, the stranded 4-lane alignment south of I-81 in this area). US 11 followed its current path to Marion (except used SR 642 through Seven Mile Ford) and appears to follow today's US 11 all the way to Wytheville. US 11 entered Wytheville on Grove Ave, then on Main St. East of Downtown, US 11 used S. 11th St and E. Withers Rd.
Adjustments: In 1931 (RR bridge date), US 11 was removed from the SR 642 loop at Seven Mile Ford.
By 1936, US 11 was removed from 11th St/Withers Road in Wytheville.
In April 1937 (CTB), US 11 was removed from the SR 754 loop in Blacksburg (west of Old Glade Spring).
In July 1937 (CTB), US 11 was removed from Colonial Ave in western Abingdon and given its current Abingdon routing.
In March 1946 (CTB), US 11 was removed from Main St in Chilhowie.
In Feb-June 1964 (CTB), US 11 was rerouted to accomodate I-81 at its interchanges near Glade Spring, Seven Mile Ford, and Atkins, leaving behind the abandoned 4-lane segment and several F-routes. Also, US 11 was rerouted to accomodate I-81 in the Mcmullen area.

Wytheville through Roanoke:
It is difficult to determine if any of the frontage roads along I-77/81 were the actual alignment of US 11. By the US 52-VA 121 interchange, the north frontage road is the correct location. US 11 followed this, then abandoned roadway through the I-77 interchange. US 11 used an abandoned alignment wedged between the frontage road and I-81, then the SR 697 loop around Carters Grove Wayside.
US 11 used the E. Lee Hwy frontage road until just before the Pulaski County Line where it dipped to the south frontage road across I-81. US 11 continued along that F-047 alignment (except the US 11-VA 100 interchange which eliminated some of the route) east to Draper, then used "Old VA 100" northeast to just past VA 99. US 11 headed west on SR 672 Lilly Rd which now ends shortly at I-81. On the other side, US 11 used McAdam Crossing Dr and Craig Loop along today's VA 99 west. US 11 then used Dora Hwy west to Pulaski. US 11 turned north on today's US 11, which it essentially followed to Dublin. US 11 probably used Peppers Ferry Rd to Main St originally, but by 1932 was using Broad St to Giles Ave south to Main St. US 11 used SR 757 Main St east from Dublin out to US 11 near Radford.
US 11 used current US 11 to the New River Bridge (except it used Warden Ct.). Once in Radford, US 11 followed current US 11 to VA 177 south, then used Auburn Ave which loops back over VA 177. US 11 followed Auburn to Rock Rd east to today's US 11 heading east, then SR 604 Plum Creek Rd. US 11 used pieces of Barringer Mtn Rd, Lynnwood Ln and Harmon Rd to get to Christiansburg.
It appears US 11 used current US 11 through Christiansburg. At the Christianburg Wayside, US 11 used SR 641 to descend the mountain then picked back up US 11-460. At Shawsville, US 11 initially used SR 753, Old Town Rd. After more US 11-460, US 11 used SR 603 Old Roanoke Rd (discontinuous) through Elliston. After more US 11-460, US 11 used SR 813 Stones Keep Ln to cross the Roanoke River. The road no longer crosses the RR and picks back up as SR 821 Joyce Ln and Peaceful Dr which runs back to US 11-460 at Wabun. At Dixie Caverns, US 11 used SR 796 Pleasant Run Dr.
US 11 used today's US 11 to Salem, turning south on College St like US 11 does now. Immediately after crossiong the river, US 11 cut east on Riverside Dr which runs back into US 11 near the VA 419 jct. US 11 then appears to have followed its routing to downtown Roanoke, then followed Commonwealth Rd to Rutherford to 7th St to US 460 to 9th St north. It is unclear if US 11 initially followed today's VA 115 to Lee Hwy or SR 601 further northeast.
Adjustments: In 1927 or 1928, US 11 was removed from 9th St/VA 115/SR 601 and placed on today's US 11 via Williamson Rd.

US 11 using 9th 1925 Auto Trails

US 11 rerouted to Williamson 1928 Official

No later than 1928, US 11 was rerouted in Roanoke to use 13th to Patterson to Campbell and also given one-way splits in Roanoke - NB used Campbell Ave while SB used Salem Ave to 3rd St back to Campbell.
Around 1931, US 11 was put on its current approach to Pulaski over Draper Mtn, which was an addition to VA 212. The old 'S' route via McAdam remained part of VA 10.

US 11 using 'S' route 1927 Official

US 11 direct to Pulaski 1932 Pulaski County

In July 1933, US 11 was removed from Riverside Dr in Salem (became VA 119 and placed on its current alignment. In 1934, US 11 was removed from Patterson in Roanoke to use Campbell from 13th. In Aug 1936 (CTB), US 11 was put on new alignment heading east out of Radford (current route). The old route along Rock Rd/Auburn Rd/VA 177 became the first US 11 ALT. US 11 East Radford 1932 Montgomery County US 11 straightened out 1936 Montgomery County In Jan 1940 (CTB), US 11 was removed from SR 697 Carter's Grove Wayside as well as the abandoned routing that is adjacent to I-81 east of the I-77 interchange. From 6/41-9/42 (CTB), US 11 was placed on its current routing from eastern Radford to Christiansburg and also removed from SR 641 descending Christiansburg Mtn. In 1945 or 1946, US 11 was placed on new routing from Dublin east to near VA 114, leaving behind US 11 ALT (see scans under 11 ALT entry) which is now SR 757. In Aug 1947 (CTB), US 11 was removed from SR 796 near Dixie Caverns. In Aug 1949 (CTB), US 11 was removed from SR 753 Shawsville and SR 764 Elliston. In May 1950 (CTB), US 11 was removed from SR 813 and SR 821 in western Roanoke County. In Nov 1962 (CTB), US 11 was rerouted to newly constructed frontage road (now F-044) north of the freeway from about the Wythe-Pulaski line eastward to SR 770 Milstead Ln near the current I-81/US 11/VA 100 interchange. The road south of the freeway is now F-047. Official maps eroneously showed US 11 still crossing over I-81 but the 1963 Pulaski County map has it right... About 1965, US 11 was removed from F-044 and placed onto I-81 directly, then replaced a short-lived VA 101 #4 north heading to Pulaski.

US 11 staying north of I-81 1963 Pulaski County

The 1975 Official is the first to show the one-way split get bigger - SB using 13th St to get from Salem Ave to Campbell instead of 2nd St.

US 11 using Patterson 1927 Official

US 11 removed from Patterson 1934 Official

US 11 one-way splits increase 1975 Official

About 1997, US 11 was removed from the SR 603 stubs in Elliston that had been the one-way northbound alignment that veered away from the southbound alignment.

Roanoke to West Virginia:
US 11 northeast of Roanoke followed its current path; It used US 11 to Buchanan except it used the SR 1001 loop near SR 604; SR 721 in Troutville; Snuffler Rd loop; SR 715 north of I-81 Exit 162; SR 1312 James River Terrace near Buchanan. In Buchanan, US 11 followed current US 11 to VA 43 south, then used Bridge St north across the James River, picking up SR 1305 on the other side. US 11 cut east on VA 43 back to current US 11 north.
US 11 followed current US 11 north, then F-054 west of I-81. About where SR 608 crosses I-81, US 11 began following F-055 (except an abandoned bridge north of SR 749) until it meets with US 11 at Exit 175. US 11 used the SR 737 loop south of Natural Bridge. North of VA 130, US 11 followed SR 743 Fanny Banger Rd across US 11 using Rices Hill Rd, then SR 686 Herring Hall Rd back to US 11 near Exit 180.
US 11 followed current US 11 through Fancy Hill, Reservation Loop near SR 739, and more US 11 (there are some visible abandoned alignments through here). US 11 used SR 764 over to VA 251, then used VA 251 and Thornhill Rd to meet US 11 Business. US 11 used Main St through Lexington, then crossed the Maury River via covered bridge just west of the current US 11 crossing. US 11 used SR 631 west to SR 681 north to (cut off by I-64) SR 750 across VA 39 to SR 645. US 11 used SR 645 northeast to US 11 near Exit 191.
US 11 used current US 11, then SR 785/716 Timber Ridge loop; several abandoned alignments along US 11 through Fairfield and Steeles Tavern to Greenville. US 11 used SR 1205 Main St through Greenville, then today's US 11 to Staunton. US 11 used today's US 11 Business through Stauton, then followed US 11 to the West Virginia line except: SR 816 Burketown; Pickering Ln at Exit 257; Tollhouse Rd in Mauertown; In Winchester it is unclear whether US 11 used Market or Braddock through downtown, but by 1928 it was using Braddock-Picadilly-Main.
Adjustments: By 1932, US 11 was removed from the SR 1001 loop in Cloverdale.
Between 1932-36, US 11 was removed from SR 737 loop south of Natural Bridge, SRs 743/686 north of Natural Bridge, and SR 717 (now 785)/716 loop Timber Ridge.

US 11 north of Natural Bridge 1932 Rockbridge County

US 11 on current alignment 1936 Rockbridge County

In March 1934 (CTB), US 11 was rerouted in Staunton to use Coalter St straight through. The old route through Downtown Staunton remained part of VA 5 and a newly designated US 11Y (now all part of US 11 Business). See scan under US 11Y entry. Note that the portion of this route within the City Limits of Staunton was placed into the state route system in July 1932 (CTB) with no apparent number. The 1932 Augusta County map showed Coalter St outside Staunton as not connecting directly to US 11.
Also in March 1934 (CTB), US 11 was removed from Tollhouse Rd in Mauertown.
In Sept 1934 (CTB), US 11 was rebuilt over some SR 717 and on new alignment north of Lexington, leaving behind VA 501, SR 750, and US 11 ALT (today these are SRs 631/681/750/645).

US 11 original routing 1932 Rockbridge County

US 11 on new routing to the east 1936 Rockbridge County

In Dec 1934 (CTB), US 11 was removed from SR 816 Burketown.
About 1934, US 11 was removed from SR 1205 Main St in Greenville.
Also in 1934, US 11 was rerouted in Winchester to use Valley and Loudoun. Braddock continued to be part of US 50 after that.
In Oct 1935 (CTB), US 11 was returned to Downtown Staunton, replacing US 11Y, Coalter St became US 11 ALT (now a little VA 254 plus unnumbered routing).
In Feb 1937 (CTB), US 11 was assigned to a bypass around the east of Buchanan for the purpose of building a new James River Bridge. It was to begin 0.2 miles north of the then-NCL of town and meet up with US 11 south of Buchanan.
In Sept 1937 (CTB), US 11's bypass for Buchanan was rescinded and the new James River Bridge was placed where it is now.
About 1938, US 11 was built on new alignment south of Lexington, leaving behind SR 764 and an extended VA 251 (now also unnumbered Thornhill Rd).
In Feb 1939 (CTB), US 11 was removed from the SR 721 loop in Troutville.
In April 1944 (CTB), US 11 was rerouted in Winchester off Valley-Loudoun and placed instead onto Braddock and North to Loudoun. The Valley-Loudoun route became US 11 ALT. See scan under US 11 ALT entries.
In Aug 1950 (CTB), US 11 was given its current one-way splits through Winchester. NB US 11 on Cameron St had not been primary routing up to this point. The short diagonal piece on Valley Ave was a replacement of part of US 11 ALT.

US 11 using Braddock 1927 Official

US 11 moved to Loudoun 1934 Official

US 11 removed from Loudoun St erroneously shown in '58 1958 Frederick County

US 11 rplaced on one-way splits 1969 Frederick County

On 6/2/50 (per July 1950 Virginia Hwy Bulletin), the US 11 Bypass of Staunton opened (early 50s maps imply it ran more around VA 261 but this is a drawing error). Official maps up through 1979 also show Coalter St as US Route and also US 11 Business route. However, the 1958 Augusta County map shows Coalter St as decommissioned. So I believe in 1950, US 11 was moved to its current bypass of Staunton. The old route through downtown Staunton became US 11 ALT (now US 11 Bus). March 1956 CTB also refers to Coalter St as SR 900.

US 11 through downtown Staunton 1932 Official

US 11 on Coalter 1934 Official

US 11 back through downtown 1937 Official

US 11 on current Staunton Bypass 1958 Augusta County

I can't find a CTB reference to designate US 11 splitting into one-way splits in Harrisonburg, there is a reference to US 11 on Liberty St in the July 1956 CTB.
In Jul 1961 (CTB), US 11 was placed onto I-81 between Exit 167 and just south of the SR 610 overpass leaving behind F-054 south of SR 608 and F-055 north of SR 608.
In May 1966 (CTB), US 11 was placed onto I-81 between just south of the SR 610 overpass to Exit 175. South of today's Peaks View Ln was abandoned and not covered by I-81 pavement (SR 610 overpass required Lee Hwy to be rebuilt a little south in order to connect), but the rest became F-055.
About 1976, US 11 was assigned to the bypass of Lexington, which had been US 11 ALT for many years. The old route through Lexington became US 11 Business.
In 2021, US 11 southbound was rerouted at buchanan to leave I-81 at Exit 167 SR 614 Arcadia then follows F-054 back to where the now-removed Exit 168 ramp was. This had been part of US 11 before I-81 existed. Northbound US 11's routing is unchanged as the on-ramp to I-81 north at Exit 168 remains.
Improvements:  Upon designation in 1926, US 11 was fully paved
The First segment of US 11 to be multilaned was from Botetourt SR 604 north to just short of Buchanan, by 1941.
By 1947, US 11 was multilaned from US 460 Roanoke to today's VA 101.
In 1949, US 11 was multilaned from Elliston to Glenvar; Fairfield to Steeles Tavern
In 1950, US 11 was multilaned through downtown Winchester.
In 1952, US 11 was multilaned from Christiansburg east a couple miles; Steeles Tavern to SR 620.
In 1953, US 11 was multilaned from VA 91 north a couple miles; Pulaski north a couple miles; VA 114 through Radford; bottom of Christiansburg Mtn to Elliston; Fairfield south a couple miles; through Stephens City.
In 1954, US 11 was multilaned from north of Pulaski to VA 100; SR 787 to VA 114; current VA 39 location to Fairfield
In 1955, US 11 was multilaned from Wytheville south a couple miles; Maury River to current VA 39.
In 1956, a 4 mile segment halfway between Chilhowie and Marion was multilaned.
In 1958, US 11 was multilaned from Wytheville north a couple miles; erroneously shown as widened from Dublin to SR 787; Mt Crawford north a couple miles
In 1960 or 1961, US 11 was multilaned from Wytheville to Carters Wayside; Strasburg area
In 1962, US 11 was multilaned from VA 117 to SR 605
In 1964, some multilaning was removed between Chilhowie and Marion as I-81 was built here; US 11 was multialned when added to I-81 from Ft. Chiswell to VA 100.
In 1965, US 11 was multilaned when added to I-81 from Buchanan to near Natural Bridge
By 1969, US 11 was multilaned from VA 112 to US 11-460 ALT
In 1975, US 11 was multilaned from VA 101 to SR 623.
In 1976, US 11 was widened from VA 140 north to US 19 split.
In Jan 2015, US 11 was 4-laned between Glenvar and VA 112.
VDOT official maps are pretty inconsistent about some parts of US 11 and its multilaning.
A fair amount of US 11 that is not 4-laned is/was 3-laned (a lot is now left center turn lane configuration today).
Posted:  Fully posted; A VA 11 shield exists in Marion
Cutouts were prevalent in Christiansburg, Staunton, and Winchester up until about 2010 but as of 2022 none remain in these cities. A couple may remain in Harrisonburg and there are still some widely sprinkled from I-81 Exit 175 north to West Virginia. Outside of Christiansburg and a couple in Marion I am not aware of any south of Exit 175.
Currently, the US 11 SB turn off Williamson onto Campbell in downtown Roanoke has not been signed for a number of years. Same goes for the US 11 NB turn off Main to College St in downtown Salem
A vintage white border shield existed in Christiansburg SB at VA 8 until between 2012-15. White border shields in Roanoke are 1990 or newer.
Multiplexes:  US 19 (13.41 mi)
US 58 ALT (0.24 mi)
US 58 (0.30 mi)
VA 16 (1.19 mi)
US 21 (0.31 mi)
I-77, I-81, US 52 (5.75 mi)
I-77, I-81 (2.28 mi)
I-81 I (8.42 mi)
US 460 Bus (3.22 mi)
US 460 (23.05 mi)
US 220 Bus, US 221, VA 116 (0.30 mi)
US 221, VA 116 (0.50 mi)
VA 43 (0.18 mi)
I-81 II (8.05 mi)
US 250 (0.07 mi)
VA 254 (0.68 mi)
US 211 (0.27 mi)
VA 55 (0.23 mi)
US 50, US 522 (0.53 mi)
US 522 (1.00 mi)
Legislative names: Lee Highway, Bristol to New Market except Staunton/Lexington Bypasses (3-20-22 designation predates US 11); Lee-Jackson Highway, Natural Bridge to Lexington (10-25-23 designation predates US 11); Lee-Jackson Memorial Highway, New Market to Winchester (3-20-22 designation predates US 11); Maury Highway, Lexington to VA 39 (5-24-23 designation predates US 11); 116th infantry Regiment Highway, Roanoke to Winchester (since 3-2-97); Woodrow Wilson Pkwy, from US 11 Bus north to VA 262 (since 2-28-66)
Gen. John H. Morgan Memorial Bridge over RR in Abingdon (2-7-40); Pioneer Memorial Bridge over Middle Fork Holston River (8-14-51); Shugart Memorial Bridge over Holston River (2-13-42); Southwest Virginia Memorial Bridge over New River (8-23-49); J. Sinclair Brown Memorial Bridge over RR in Salem (3-6-48); William Peace Hunter Bridge over RR in Roanoke (8-9-56); Veterans Memorial Bridge over Maury River (2-15-2001)
Other names:  Euclid Ave (Bristol); Main St (Abingdon); Main St (Marion); 12th St/Main St (Wytheville); Washington Ave/5th St (Pulaski); Broad St (Dublin); Norwood St/Main St (Radford); Radford Rd (Radford to Christiansburg); Radford St/Main St/Roanoke St (Christiansburg); Roanoke Rd (Christiansburg to Roanoke Co); Main St/College Ave/Colorado St/Apperson Dr (Salem); Brandon Ave/Grandin Rd/Memorial Ave/Campbell Ave/Williamson Rd (Roanoke); Main St (Buchanan); Greenville Ave/Commerce Rd (Staunton); Main St (Harrisonburg); VAlley Pike (Harrisonburg to New Market); Congress St (New Market); Old Valley Pike (Shenandoah/Warren Counties); Main St (Mt. Jackson); Main St (Edinburg); Main St (Woodstock); Main St (Toms Brook); Stover Ave/King St/Massanutten St (Strasburg); Valley Pike (Frederick Co s of Winchester); Main St (Middletown); Main St (Stephens City); Valley Ave/Gerrard St/Cameron St/Braddock St (Winchester); Martinsburg Pike (Frederick Co n of Winchester)
Scenic Byway:  VA 130 to SCL Lexington (12-18-97)
Comments: US 11 is never far from I-81 anywhere it runs in Virginia. However, it often runs out of sight of the interstate and is in many places a lovely mountain valley drive.
US 11 is pretty busy in the multiple cities it traverses, however.